HPE-ProLiant ML350 Gen10
The HPE ProLiant ML350 Gen10 is a versatile 2-socket tower server designed for small and medium-sized businesses, branch offices, and enterprise environments. Supporting Intel Xeon Scalable processors, up to 3TB of DDR4 memory, extensive SAS/SATA storage, optional NVMe drives, HPE Smart Array RAID, and HPE iLO 5 management, it provides enterprise-class performance, expandability, and reliability in a tower form factor.
Description
The HPE ProLiant ML350 Gen10 is a powerful and highly expandable tower server designed to deliver enterprise-class computing capabilities in a flexible chassis. Its dual-processor architecture, large memory capacity, extensive storage options, and PCIe expansion make it suitable for a wide range of business and infrastructure workloads.
The ML350 Gen10 is particularly useful where organizations need the capabilities of a data-center server but prefer a tower form factor for office, branch-office, or small server-room deployment.
Powerful Intel Xeon Scalable Processing
The ML350 Gen10 supports Intel Xeon Scalable processors, including Xeon Bronze, Silver, Gold, and Platinum models.
With two processor sockets, the server can be deployed with one or two CPUs, allowing organizations to scale processing capacity as their workloads grow.
Depending on the selected processor, configurations can provide substantial core and thread counts for:
- Virtualization
- Databases
- ERP applications
- Business applications
- File and print services
- Cloud infrastructure
- Data analytics
- Server consolidation
High-Capacity DDR4 ECC Memory
The ML350 Gen10 provides 24 DDR4 DIMM slots and supports ECC Registered and Load-Reduced memory.
With supported configurations, the platform can accommodate up to 3TB of DDR4 memory.
This large memory capacity makes the server suitable for:
- Virtualization
- Large databases
- In-memory applications
- Data analytics
- Business applications
- Multi-user environments
ECC memory helps detect and correct certain memory errors, improving data integrity and system reliability.
Extensive Storage Capacity
One of the major advantages of the ML350 Gen10 is its extensive internal storage capability.
Depending on chassis and backplane configuration, the server can support both LFF and SFF drive configurations.
Supported storage technologies include:
- SAS HDD
- SATA HDD
- SAS SSD
- SATA SSD
- NVMe SSD, configuration dependent
The tower form factor provides considerably more internal storage flexibility than many compact rack servers, making the ML350 Gen10 particularly suitable for capacity-intensive workloads.
HPE Smart Array RAID
The ML350 Gen10 supports HPE Smart Array storage controllers for enterprise RAID and storage management.
Depending on the installed controller, RAID configurations can include:
- RAID 0
- RAID 1
- RAID 5
- RAID 6
- RAID 10
- RAID 50
- RAID 60
The exact RAID levels and advanced storage features depend on the specific Smart Array controller installed.
NVMe Storage Support
Selected configurations support NVMe SSDs, providing high-speed, low-latency storage for demanding applications.
NVMe is particularly beneficial for:
- Databases
- Virtualization
- High-transaction workloads
- Analytics
- Application acceleration
- High-performance computing
The number of NVMe drives supported depends on the selected backplane and configuration.
Extensive PCIe Expansion
The ML350 Gen10 offers extensive PCIe expansion capability, making it highly adaptable to specialized business requirements.
Expansion cards can include:
- Network adapters
- Fibre Channel HBAs
- Storage controllers
- GPU accelerators
- Graphics cards
- High-speed networking adapters
- Specialized PCIe devices
This flexibility allows the server to evolve as business and application requirements change.
Advanced Networking
The ML350 Gen10 supports a wide range of HPE networking options.
Depending on configuration, available networking technologies can include:
- 1Gb Ethernet
- 10Gb Ethernet
- 25Gb Ethernet
- Fibre Channel
- FlexibleLOM adapters
- PCIe network adapters
This makes the ML350 Gen10 suitable for standard business networks as well as high-speed virtualization and storage environments.
HPE iLO 5 Remote Management
The ML350 Gen10 incorporates HPE Integrated Lights-Out 5 (iLO 5) for remote server management.
Administrators can remotely:
- Monitor server health
- Access the remote console
- Control server power
- Review hardware status
- Manage firmware
- Troubleshoot system problems
- Perform remote administration
This reduces the need for physical access to the server and simplifies IT management.
Enterprise-Class Reliability
The ML350 Gen10 incorporates numerous reliability features designed for business-critical environments.
Depending on configuration, these can include:
- ECC memory
- Hot-plug drives
- Redundant power supplies
- Hot-plug fans
- HPE Smart Array RAID
- HPE iLO 5
- Redundant cooling
- Enterprise-grade components
These features help minimize downtime and simplify maintenance.
Tower Form Factor
Unlike the DL-series rack servers, the ML350 Gen10 uses a tower chassis, making it suitable for environments where a rack-mounted infrastructure is not required.
The tower design makes it particularly convenient for:
- Small businesses
- Branch offices
- Retail locations
- Professional offices
- Small server rooms
- Remote sites
The server can also be converted or installed in rack environments using appropriate HPE rack-mount options.
Ideal Applications
The HPE ProLiant ML350 Gen10 is well suited for:
- Small and medium-sized businesses
- Enterprise branch offices
- Virtualization
- VMware
- Microsoft Hyper-V
- Database servers
- ERP applications
- File and print servers
- Backup and recovery
- Web and application servers
- Private cloud
- Business applications
- Server consolidation
- General-purpose enterprise workloads
Key Specifications
| Feature | Specification |
|---|---|
| Product | HPE ProLiant ML350 Gen10 |
| Form Factor | Tower / Rack Convertible |
| Processor | Intel Xeon Scalable |
| CPU Sockets | 2 |
| Memory | DDR4 ECC RDIMM / LRDIMM |
| DIMM Slots | 24 |
| Maximum Memory | Up to 3TB |
| Storage | SAS / SATA / SSD / NVMe options |
| Drive Form Factors | SFF / LFF, configuration dependent |
| RAID | HPE Smart Array |
| Networking | 1GbE / 10GbE / 25GbE and other options |
| Expansion | Multiple PCIe slots |
| Remote Management | HPE iLO 5 |
| Power | HPE hot-plug / redundant PSU options |
| Intended Use | Business / Enterprise / Data Center |
Configuration Note
The HPE ProLiant ML350 Gen10 was offered in numerous configurations. The exact Xeon processor, number of CPUs, RAM capacity, storage backplane, drive count, RAID controller, network adapters, GPU, power supplies, and operating system can vary substantially between individual units.



